| 17. Round | 21/08/2021 | Club San José | - | Always Ready | 0:4 | ||||
| 23. Round | 22/10/2021 | Club San José | - | Club Aurora | 1:4 | ||||
| 26. Round | 22/11/2021 | Club San José | - | Real Santa Cruz | 1:2 | ||||
| 27. Round | 26/11/2021 | Nacional Potosí | - | Club San José | 7:1 | ||||
| 28. Round | 30/11/2021 | Club San José | - | Oriente Petrolero | 0:2 | ||||
| 29. Round | 05/12/2021 | The Strongest | - | Club San José | 2:0 |
Bolivia