| 1. Round | 28/01/2018 | Sport Boys Warnes | - | CD Guabirá | 1:1 |  |
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| 2. Round | 04/02/2018 | Sport Boys Warnes | - | Blooming | 0:2 | |
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| 3. Round | 07/02/2018 | Club Aurora | - | Sport Boys Warnes | 2:2 | |
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| 4. Round | 17/02/2018 | Sport Boys Warnes | - | Club San José | 0:0 | |
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| 5. Round | 25/02/2018 | Nacional Potosí | - | Sport Boys Warnes | 3:0 | ||||
| 6. Round | 03/03/2018 | Sport Boys Warnes | - | The Strongest | 3:2 | |
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| 7. Round | 08/03/2018 | Royal Pari | - | Sport Boys Warnes | 1:2 | ||||
| 8. Round | 11/03/2018 | CD Guabirá | - | Sport Boys Warnes | 1:1 | ||||
| 9. Round | 19/03/2018 | Blooming | - | Sport Boys Warnes | 1:0 | ||||
| 10. Round | 03/04/2018 | Sport Boys Warnes | - | Club Aurora | 1:2 | ||||
| 11. Round | 08/04/2018 | Club San José | - | Sport Boys Warnes | 4:0 | ||||
| 12. Round | 17/04/2018 | Sport Boys Warnes | - | Nacional Potosí | 4:0 | ||||
| 13. Round | 21/04/2018 | The Strongest | - | Sport Boys Warnes | 3:0 | ||||
| 14. Round | 28/04/2018 | Sport Boys Warnes | - | Royal Pari | 0:0 |
Paraguay