| 1. Round | 04/02/2012 | Tacuary | - | Club Rubio Ñu | 0:1 | ||||
| 4. Round | 26/02/2012 | Club Rubio Ñu | - | Club Olimpia | 2:3 |  |
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| 5. Round | 04/03/2012 | Cerro Porteño | - | Club Rubio Ñu | 5:3 | ||||
| 8. Round | 24/03/2012 | Club Rubio Ñu | - | Independiente CG | 2:1 | ||||
| 10. Round | 07/04/2012 | Club Nacional | - | Club Rubio Ñu | 0:2 | ||||
| 11. Round | 16/04/2012 | Club Rubio Ñu | - | Libertad | 1:5 | ||||
| 14. Round | 29/04/2012 | Club Rubio Ñu | - | Sol de América | 0:3 |  |
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| 17. Round | 12/06/2012 | Sportivo Carapeguá | - | Club Rubio Ñu | 2:1 | ||||
| 22. Round | 07/07/2012 | Libertad | - | Club Rubio Ñu | 1:0 | |
Paraguay