| 1. Round | 24/02/2022 | Academia Puerto Cabello | - | Portuguesa FC | 1:1 |  |
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| 2. Round | 06/03/2022 | Portuguesa FC | - | Mineros de Guayana | 0:2 | ||||
| 3. Round | 11/03/2022 | Monagas | - | Portuguesa FC | 2:4 | |
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| 4. Round | 19/03/2022 | Portuguesa FC | - | Zulia FC | 1:1 | ||||
| 5. Round | 26/03/2022 | Caracas FC | - | Portuguesa FC | 1:1 | ||||
| 6. Round | 03/04/2022 | Portuguesa FC | - | Universidad Central | 0:0 | ||||
| 7. Round | 08/04/2022 | Deportivo Lara | - | Portuguesa FC | 1:0 | ||||
| 8. Round | 16/04/2022 | Portuguesa FC | - | Estudiantes de Mérida | 2:1 |  |
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| 9. Round | 21/04/2022 | Carabobo FC | - | Portuguesa FC | 0:0 | |
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| 10. Round | 01/05/2022 | Portuguesa FC | - | Metropolitanos FC | 0:0 | ||||
| 11. Round | 06/05/2022 | Zamora FC | - | Portuguesa FC | 0:0 | ||||
| 15. Round | 03/06/2022 | Portuguesa FC | - | Deportivo La Guaira | 1:0 | ||||
| 17. Round | 16/06/2022 | Portuguesa FC | - | Aragua FC | 1:0 |
Argentina