| 1. Round | 06/01/2022 | Alebrijes de Oaxaca | - | Cancún FC | 2:0 | ||||
| 3. Round | 20/01/2022 | Alebrijes de Oaxaca | - | Leones Negros | 1:1 | ||||
| 4. Round | 26/01/2022 | CF Monterrey II | - | Alebrijes de Oaxaca | 2:0 |  |
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| 6. Round | 01/02/2022 | Tepatitlán | - | Alebrijes de Oaxaca | 1:2 | ||||
| 12. Round | 16/03/2022 | Alebrijes de Oaxaca | - | Coyotes de Tlaxcala | 2:1 |
Mexico