| 2. Round | 30/01/2016 | Club Olimpia | - | Libertad | 1:0 | ||||
| 8. Round | 02/03/2016 | Libertad | - | Cerro Porteño | 2:1 | ||||
| 9. Round | 06/03/2016 | Sportivo Luqueño | - | Libertad | 0:1 | ||||
| 10. Round | 11/03/2016 | Libertad | - | General Caballero ZC | 2:2 | ||||
| 11. Round | 20/03/2016 | Guaraní | - | Libertad | 1:3 | ||||
| 12. Round | 03/04/2016 | Club Rubio Ñu | - | Libertad | 2:0 |  |
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| 15. Round | 17/04/2016 | River Plate | - | Libertad | 1:3 | ||||
| 16. Round | 21/04/2016 | Libertad | - | Club Nacional | 4:3 | |
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| 17. Round | 25/04/2016 | Deportivo Capiatá | - | Libertad | 0:2 | ||||
| 13. Round | 28/04/2016 | Libertad | - | Club Olimpia | 3:1 | |
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| 18. Round | 02/05/2016 | Libertad | - | General Díaz | 2:1 | |
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| 19. Round | 05/05/2016 | Cerro Porteño | - | Libertad | 0:1 | ||||
| 20. Round | 09/05/2016 | Libertad | - | Sportivo Luqueño | 1:0 | ||||
| 21. Round | 15/05/2016 | General Caballero ZC | - | Libertad | 0:2 | ||||
| 22. Round | 21/05/2016 | Libertad | - | Guaraní | 0:0 |
Paraguay