| 2. Round | 23/01/2010 | Estudiantes Tecos | - | Puebla FC | 2:3 | ||||
| 4. Round | 07/02/2010 | Atlante | - | Puebla FC | 1:1 | ||||
| 9. Round | 07/03/2010 | Pumas UNAM | - | Puebla FC | 4:1 | ||||
| 10. Round | 14/03/2010 | Puebla FC | - | CF Monterrey | 1:1 | ||||
| 12. Round | 29/03/2010 | Puebla FC | - | CF América | 2:1 | ||||
| 13. Round | 04/04/2010 | Monarcas Morelia | - | Puebla FC | 1:1 |
Mexico