| 1. Round | 25/07/2010 | Deportivo Guadalajara | - | Puebla FC | 0:0 | ||||
| 2. Round | 01/08/2010 | Puebla FC | - | Club San Luis | 2:1 |  |
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| 3. Round | 08/08/2010 | Estudiantes Tecos | - | Puebla FC | 1:3 | ||||
| 4. Round | 15/08/2010 | Puebla FC | - | Atlante | 1:1 | ||||
| 5. Round | 22/08/2010 | Pumas UNAM | - | Puebla FC | 4:1 | |
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| 6. Round | 29/08/2010 | Puebla FC | - | CF Pachuca | 3:1 | ||||
| 7. Round | 11/09/2010 | Jaguares Chiapas | - | Puebla FC | 4:0 | ||||
| 8. Round | 19/09/2010 | Puebla FC | - | UANL Tigres | 1:3 | ||||
| 9. Round | 26/09/2010 | Atlas Guadalajara | - | Puebla FC | 1:0 | ||||
| 12. Round | 17/10/2010 | Puebla FC | - | CF América | 2:2 | |
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| 16. Round | 07/11/2010 | Puebla FC | - | CF Monterrey | 2:0 | ||||
| 17. Round | 14/11/2010 | Monarcas Morelia | - | Puebla FC | 3:3 |
Mexico