6. Round | 16/10/2021 | Nacional | - | Boston River | 3:2 | ||||
8. Round | 24/10/2021 | Liverpool | - | Boston River | 2:2 | ||||
10. Round | 04/11/2021 | Cerro Largo | - | Boston River | 1:1 | ||||
12. Round | 14/11/2021 | Sud América | - | Boston River | 1:2 | ||||
15. Round | 04/12/2021 | Boston River | - | Deportivo Maldonado | 2:1 |