| 1. Round | 22/01/2019 | San Lorenzo | - | River Plate | 1:0 | ||||
| 2. Round | 28/01/2019 | River Plate | - | Sportivo Luqueño | 2:1 | ||||
| 3. Round | 02/02/2019 | Deportivo Santaní | - | River Plate | 1:1 | ||||
| 4. Round | 05/02/2019 | River Plate | - | Sol de América | 1:0 | ||||
| 8. Round | 26/02/2019 | River Plate | - | General Díaz | 3:2 |  |
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| 9. Round | 04/03/2019 | Guaraní | - | River Plate | 2:1 | ||||
| 10. Round | 09/03/2019 | Club Olimpia | - | River Plate | 0:0 | ||||
| 12. Round | 23/03/2019 | River Plate | - | San Lorenzo | 2:1 | ||||
| 13. Round | 01/04/2019 | Sportivo Luqueño | - | River Plate | 3:1 | ||||
| 14. Round | 03/04/2019 | River Plate | - | Deportivo Santaní | 1:2 | ||||
| 15. Round | 08/04/2019 | Sol de América | - | River Plate | 0:1 | ||||
| 16. Round | 14/04/2019 | River Plate | - | Cerro Porteño | 1:5 |
Paraguay