| 1. Round | 06/08/2005 | San Lorenzo | - | Vélez Sarsfield | 3:2 | ||||
| 2. Round | 14/08/2005 | Estudiantes | - | San Lorenzo | 0:1 |  |
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| 3. Round | 21/08/2005 | San Lorenzo | - | Independiente | 1:1 | |
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| 4. Round | 27/08/2005 | Olimpo de Bahía Blanca | - | San Lorenzo | 1:1 | ||||
| 5. Round | 07/09/2005 | San Lorenzo | - | Boca Juniors | 3:2 |  |
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| 6. Round | 11/09/2005 | Rosario Central | - | San Lorenzo | 0:4 | ||||
| 7. Round | 17/09/2005 | San Lorenzo | - | Lanús | 1:1 | ||||
| 8. Round | 25/09/2005 | Instituto de Córdoba | - | San Lorenzo | 2:0 | ||||
| 9. Round | 01/10/2005 | San Lorenzo | - | Gimnasia de Jujuy | 1:1 | ||||
| 10. Round | 06/10/2005 | San Lorenzo | - | Argentinos Juniors | 1:3 | ||||
| 11. Round | 15/10/2005 | Gimnasia de La Plata | - | San Lorenzo | 3:2 | ||||
| 12. Round | 30/10/2005 | San Lorenzo | - | Racing Club | 2:1 | |
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| 13. Round | 09/11/2005 | Quilmes | - | San Lorenzo | 2:0 | ||||
| 14. Round | 13/11/2005 | San Lorenzo | - | Tiro Federal de Rosario | 5:3 | ||||
| 15. Round | 17/11/2005 | River Plate | - | San Lorenzo | 5:1 | ||||
| 16. Round | 22/11/2005 | San Lorenzo | - | Newell's Old Boys | 4:2 | |
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| 18. Round | 04/12/2005 | San Lorenzo | - | Colón de Santa Fe | 1:4 | ||||
| 19. Round | 11/12/2005 | Arsenal de Sarandí | - | San Lorenzo | 1:2 |  |
Argentina