| 3. Round | 24/08/2008 | San Lorenzo | - | Estudiantes | 3:0 |  |
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| 4. Round | 31/08/2008 | River Plate | - | San Lorenzo | 0:0 | |
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| 5. Round | 13/09/2008 | San Lorenzo | - | Rosario Central | 2:1 | ||||
| 6. Round | 16/09/2008 | Banfield | - | San Lorenzo | 1:3 |  |
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| 7. Round | 19/09/2008 | San Lorenzo | - | Colón de Santa Fe | 3:0 | |
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| 8. Round | 27/09/2008 | San Lorenzo | - | Arsenal de Sarandí | 2:0 | |
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| 9. Round | 04/10/2008 | Vélez Sarsfield | - | San Lorenzo | 0:1 | ||||
| 10. Round | 18/10/2008 | San Lorenzo | - | San Martín de Tucumán | 1:0 | ||||
| 11. Round | 26/10/2008 | Racing Club | - | San Lorenzo | 2:1 | |
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| 12. Round | 29/10/2008 | San Lorenzo | - | Gimnasia de La Plata | 1:1 | ||||
| 13. Round | 02/11/2008 | Boca Juniors | - | San Lorenzo | 1:0 | |
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| 14. Round | 09/11/2008 | San Lorenzo | - | Gimnasia de Jujuy | 2:1 | ||||
| 15. Round | 15/11/2008 | Newell's Old Boys | - | San Lorenzo | 3:3 | |
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| 16. Round | 22/11/2008 | San Lorenzo | - | Lanús | 1:3 | |
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| 18. Round | 07/12/2008 | San Lorenzo | - | Independiente | 4:1 | |
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| 19. Round | 14/12/2008 | Argentinos Juniors | - | San Lorenzo | 0:1 | |
Argentina