| 1. Round | 25/02/2020 | Santiago Morning | - | Cobreloa | 0:1 | ||||
| 2. Round | 01/03/2020 | Cobreloa | - | San Marcos | 3:1 |  |
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| 3. Round | 07/03/2020 | Barnechea | - | Cobreloa | 2:2 | ||||
| 4. Round | 15/03/2020 | Cobreloa | - | CD Magallanes | 0:1 | ||||
| 5. Round | 29/08/2020 | Deportes Copiapó | - | Cobreloa | 1:2 | ||||
| 6. Round | 06/09/2020 | Cobreloa | - | Santa Cruz | 0:1 | ||||
| 8. Round | 13/09/2020 | Rangers | - | Cobreloa | 3:1 | ||||
| 7. Round | 20/09/2020 | Deportes Valdivia | - | Cobreloa | 1:1 | ||||
| 10. Round | 23/09/2020 | Cobreloa | - | Unión San Felipe | 0:2 | ||||
| 11. Round | 27/09/2020 | Puerto Montt | - | Cobreloa | 1:0 | ||||
| 12. Round | 30/09/2020 | Cobreloa | - | Deportes Temuco | 1:0 | ||||
| 13. Round | 05/10/2020 | Ñublense | - | Cobreloa | 3:2 | ||||
| 26. Round | 18/12/2020 | Cobreloa | - | Puerto Montt | 1:1 | ||||
| 27. Round | 22/12/2020 | CD Magallanes | - | Cobreloa | 1:1 | ||||
| 28. Round | 30/12/2020 | Cobreloa | - | Deportes Melipilla | 0:0 | ||||
| 18. Round | 06/01/2021 | Cobreloa | - | Deportes Valdivia | 6:0 | |
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| 30. Round | 17/01/2021 | Deportes Temuco | - | Cobreloa | 1:0 |
Chile