| 3. Round | 03/08/2019 | Puebla FC | - | Deportivo Guadalajara | 1:1 | ||||
| 4. Round | 12/08/2019 | Santos Laguna | - | Puebla FC | 4:1 | ||||
| 5. Round | 17/08/2019 | Puebla FC | - | CF Pachuca | 0:4 | ||||
| 6. Round | 25/08/2019 | Cruz Azul | - | Puebla FC | 1:1 | ||||
| 7. Round | 30/08/2019 | Puebla FC | - | FC Juárez | 2:1 | ||||
| 8. Round | 01/09/2019 | Gallos Blancos | - | Puebla FC | 1:1 |  |
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| 9. Round | 14/09/2019 | Puebla FC | - | Atlético San Luis | 1:3 | ||||
| 10. Round | 21/09/2019 | CF Monterrey | - | Puebla FC | 3:2 | ||||
| 11. Round | 25/09/2019 | UANL Tigres | - | Puebla FC | 0:1 | ||||
| 12. Round | 28/09/2019 | Puebla FC | - | Club León | 2:1 | ||||
| 13. Round | 06/10/2019 | Deportivo Toluca | - | Puebla FC | 1:1 | ||||
| 14. Round | 19/10/2019 | Puebla FC | - | Atlas Guadalajara | 0:1 |  |
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| 15. Round | 27/10/2019 | CF América | - | Puebla FC | 2:0 | ||||
| 16. Round | 30/10/2019 | CD Veracruz | - | Puebla FC | 1:0 | |
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| 17. Round | 02/11/2019 | Puebla FC | - | Pumas UNAM | 1:1 | ||||
| 18. Round | 09/11/2019 | Monarcas Morelia | - | Puebla FC | 3:2 | |
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| 19. Round | 23/11/2019 | Puebla FC | - | Club Necaxa | 3:0 | |
Mexico