| 1. Round | 09/01/2021 | Atlas Guadalajara | - | CF Monterrey | 0:2 | ||||
| 2. Round | 18/01/2021 | Gallos Blancos | - | Atlas Guadalajara | 1:0 |  |
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| 4. Round | 31/01/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 6. Round | 16/02/2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 | ||||
| 9. Round | 02/03/2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | ||||
| 10. Round | 06/03/2021 | Atlas Guadalajara | - | FC Juárez | 2:0 | ||||
| 11. Round | 13/03/2021 | Puebla FC | - | Atlas Guadalajara | 0:1 | ||||
| 13. Round | 04/04/2021 | Atlas Guadalajara | - | Club Tijuana | 1:0 |
Mexico