| 1. Round | 01/08/2022 | Liverpool | - | Defensor Sporting | 1:3 | ||||
| 2. Round | 08/08/2022 | Albion | - | Liverpool | 1:1 | ||||
| 3. Round | 14/08/2022 | Liverpool | - | Nacional | 0:1 | ||||
| 6. Round | 20/08/2022 | Rentistas | - | Liverpool | 0:2 | ||||
| 5. Round | 28/08/2022 | Liverpool | - | Deportivo Maldonado | 1:1 | ||||
| 4. Round | 03/09/2022 | Danubio | - | Liverpool | 1:1 |  |
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| 7. Round | 09/09/2022 | Liverpool | - | Cerrito | 3:0 | ||||
| 8. Round | 15/09/2022 | Liverpool | - | Peñarol | 0:1 | ||||
| 9. Round | 19/09/2022 | Montevideo City Torque | - | Liverpool | 0:2 | |
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| 10. Round | 24/09/2022 | Liverpool | - | Montevideo Wanderers | 1:1 | ||||
| 11. Round | 01/10/2022 | Plaza Colonia | - | Liverpool | 1:3 | ||||
| 14. Round | 16/10/2022 | Liverpool | - | Cerro Largo | 1:0 | |
Uruguay