| 1. Round | 15/01/2022 | Sporting Canamy | - | Lobos ULMX | 2:2 | ||||
| 2. Round | 23/01/2022 | Reboceros de La Piedad | - | Sporting Canamy | 1:1 | ||||
| 3. Round | 29/01/2022 | Sporting Canamy | - | Deportivo Dongu | 2:1 | ||||
| 4. Round | 05/02/2022 | Cañoneros FC | - | Sporting Canamy | 1:3 | ||||
| 6. Round | 22/02/2022 | Escorpiones | - | Sporting Canamy | 0:1 | ||||
| 7. Round | 26/02/2022 | Sporting Canamy | - | Cafetaleros de Chiapas | 1:1 | ||||
| 9. Round | 12/03/2022 | Sporting Canamy | - | Inter de Querétaro | 2:0 |  |
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| 10. Round | 20/03/2022 | Montañeses FC | - | Sporting Canamy | 1:0 | ||||
| 8. Round | 24/03/2022 | CD Zap | - | Sporting Canamy | 2:1 | |
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| 11. Round | 28/03/2022 | Sporting Canamy | - | Leviatán FC | 3:1 | ||||
| 12. Round | 02/04/2022 | Sporting Canamy | - | Inter Playa | 1:2 |  |
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| 13. Round | 10/04/2022 | Yalmakan FC | - | Sporting Canamy | 2:0 |  |
Mexico