| 1. Round | 08/01/2022 | Pumas UNAM [U16] | - | Cruz Azul [U16] | 1:2 | ||||
| 3. Round | 22/01/2022 | Pumas UNAM [U16] | - | FC Juárez [U16] | 3:0 | ||||
| 6. Round | 12/02/2022 | Gallos Blancos [U16] | - | Pumas UNAM [U16] | 0:1 | ||||
| 7. Round | 19/02/2022 | Puebla FC [U16] | - | Pumas UNAM [U16] | 0:1 | ||||
| 9. Round | 05/03/2022 | Pumas UNAM [U16] | - | Club Necaxa [U16] | 1:1 | ||||
| 10. Round | 11/03/2022 | FC Juárez [U16] | - | Pumas UNAM [U16] | 2:3 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM [U16] | - | CF América [U16] | 1:0 | ||||
| 15. Round | 23/03/2022 | Cruz Azul [U16] | - | Pumas UNAM [U16] | 0:2 | ||||
| 12. Round | 26/03/2022 | CF Pachuca [U16] | - | Pumas UNAM [U16] | 0:0 | ||||
| 14. Round | 30/03/2022 | Pumas UNAM [U16] | - | Gallos Blancos [U16] | 3:0 |  |
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| 16. Round | 23/04/2022 | Pumas UNAM [U16] | - | Deportivo Toluca [U16] | 3:4 | ||||
| 17. Round | 30/04/2022 | Club Necaxa [U16] | - | Pumas UNAM [U16] | 2:1 | ||||
| 18. Round | 07/05/2022 | Pumas UNAM [U16] | - | Puebla FC [U16] | 1:1 |
Mexico