| 2. Round | 02/08/2020 | Deportivo Toluca | - | Atlético San Luis | 3:2 | ||||
| 7. Round | 30/08/2020 | Atlético San Luis | - | CF América | 1:2 | ||||
| 9. Round | 08/09/2020 | Atlético San Luis | - | Club Necaxa | 2:1 | ||||
| 10. Round | 13/09/2020 | Pumas UNAM | - | Atlético San Luis | 3:0 | ||||
| 11. Round | 21/09/2020 | Atlético San Luis | - | CF Monterrey | 1:2 | ||||
| 12. Round | 27/09/2020 | Atlético San Luis | - | Club León | 0:2 | ||||
| 13. Round | 04/10/2020 | UANL Tigres | - | Atlético San Luis | 3:0 | ||||
| 14. Round | 16/10/2020 | Atlético San Luis | - | Gallos Blancos | 2:1 |  |
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| 15. Round | 26/10/2020 | Santos Laguna | - | Atlético San Luis | 2:1 | ||||
| 16. Round | 30/10/2020 | Atlético San Luis | - | Mazatlán FC | 0:5 | ||||
| 17. Round | 07/11/2020 | Puebla FC | - | Atlético San Luis | 1:0 |
Mexico