1. Round | 07/02/2022 | River Plate | - | Montevideo Wanderers | 1:1 | ||||
2. Round | 12/02/2022 | Plaza Colonia | - | River Plate | 0:1 | ||||
3. Round | 19/02/2022 | River Plate | - | Boston River | 1:2 | ||||
4. Round | 28/02/2022 | River Plate | - | Cerrito | 3:1 | ||||
6. Round | 20/03/2022 | River Plate | - | Fénix | 3:1 | ||||
7. Round | 03/04/2022 | Defensor Sporting | - | River Plate | 3:2 | ||||
10. Round | 23/04/2022 | River Plate | - | Danubio | 0:0 | ||||
11. Round | 07/05/2022 | Deportivo Maldonado | - | River Plate | 2:1 | ||||
12. Round | 13/05/2022 | River Plate | - | Rentistas | 1:0 | ||||
13. Round | 22/05/2022 | Liverpool | - | River Plate | 2:1 |