| 12. Round | 11/05/2025 | Houston Dynamo | - | Seattle Sounders | 1:3 | ||||
| 13. Round | 15/05/2025 | Houston Dynamo | - | Minnesota United FC | 2:0 |  |
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| 14. Round | 18/05/2025 | FC Dallas | - | Houston Dynamo | 0:2 | ||||
| 15. Round | 25/05/2025 | San Jose Earthquakes | - | Houston Dynamo | 3:3 | |
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| 16. Round | 29/05/2025 | New York City FC | - | Houston Dynamo | 0:3 | ||||
| 17. Round | 01/06/2025 | Houston Dynamo | - | Sporting Kansas City | 1:3 |
Colombia