| 1. Round | 18/09/2021 | Cañoneros FC | - | Inter de Querétaro | 0:1 | ||||
| 5. Round | 13/10/2021 | Cañoneros FC | - | Yalmakan FC | 0:1 | ||||
| 6. Round | 18/10/2021 | Lobos ULMX | - | Cañoneros FC | 2:3 |  |
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| 7. Round | 23/10/2021 | Cañoneros FC | - | Reboceros de La Piedad | 0:2 | ||||
| 8. Round | 30/10/2021 | Deportivo Dongu | - | Cañoneros FC | 1:0 | ||||
| 12. Round | 20/11/2021 | Cañoneros FC | - | Cafetaleros de Chiapas | 1:3 | |
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| 13. Round | 26/11/2021 | CD Zap | - | Cañoneros FC | 6:2 | |
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Mexico