| 1. Round | 25/07/2010 | The Strongest | - | Club Aurora | 4:2 |  |
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| 2. Round | 01/08/2010 | Bolívar | - | The Strongest | 2:2 |  |
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| 3. Round | 08/08/2010 | The Strongest | - | Real Mamoré | 3:0 | |
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| 4. Round | 15/08/2010 | Club San José | - | The Strongest | 3:2 | |
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| 5. Round | 22/08/2010 | The Strongest | - | Universitario de Sucre | 3:0 | |
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| 6. Round | 29/08/2010 | Blooming | - | The Strongest | 2:1 | |
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| 7. Round | 04/09/2010 | The Strongest | - | Jorge Wilstermann | 2:1 | ||||
| 8. Round | 09/09/2010 | The Strongest | - | La Paz FC | 1:3 | |
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| 9. Round | 11/09/2010 | CD Guabirá | - | The Strongest | 2:1 | |
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| 10. Round | 19/09/2010 | The Strongest | - | Real Potosí | 4:2 | |
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| 11. Round | 26/09/2010 | Oriente Petrolero | - | The Strongest | 4:0 | ||||
| 13. Round | 14/10/2010 | The Strongest | - | Bolívar | 3:2 | |
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| 15. Round | 17/10/2010 | The Strongest | - | Club San José | 1:2 | |
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| 18. Round | 31/10/2010 | Jorge Wilstermann | - | The Strongest | 3:1 | |
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| 17. Round | 04/11/2010 | The Strongest | - | Blooming | 2:1 | |
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| 20. Round | 14/11/2010 | The Strongest | - | CD Guabirá | 1:0 | |
Argentina