| 4. Round | 29/10/2000 | Ethnikos Asteras | - | Panachaiki GE | 3:1 | ||||
| 5. Round | 05/11/2000 | Panachaiki GE | - | Ionikos Nikea | 2:3 | ||||
| 18. Round | 10/02/2001 | Athinaikos | - | Panachaiki GE | 3:1 | ||||
| 20. Round | 24/02/2001 | Ionikos Nikea | - | Panachaiki GE | 3:1 |  |
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| 22. Round | 10/03/2001 | Panachaiki GE | - | Olympiakos Piraeus | 1:5 | ||||
| 23. Round | 17/03/2001 | PS Kalamata | - | Panachaiki GE | 3:3 |  |
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| 24. Round | 31/03/2001 | Panachaiki GE | - | PAS Giannina | 2:1 | ||||
| 25. Round | 07/04/2001 | Panionios GSS | - | Panachaiki GE | 2:0 | ||||
| 26. Round | 19/04/2001 | Panachaiki GE | - | Aris Saloniki | 4:1 | |
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| 27. Round | 28/04/2001 | OFI Heraklion | - | Panachaiki GE | 0:1 | ||||
| 28. Round | 05/05/2001 | Panachaiki GE | - | Paniliakos Pyrgos | 3:0 | ||||
| 29. Round | 19/05/2001 | Panathinaikos | - | Panachaiki GE | 4:0 | ||||
| 30. Round | 26/05/2001 | PAOK Saloniki | - | Panachaiki GE | 5:1 |
Greece