| 3. Round | 19/02/2022 | Club Aurora | - | Atlético Palmaflor | 1:2 | ||||
| 4. Round | 27/02/2022 | Universitario de Sucre | - | Club Aurora | 1:1 | ||||
| 5. Round | 06/03/2022 | Real Santa Cruz | - | Club Aurora | 2:2 | ||||
| 6. Round | 13/03/2022 | Club Aurora | - | Jorge Wilstermann | 1:0 | ||||
| 8. Round | 11/04/2022 | Club Aurora | - | The Strongest | 1:0 | ||||
| 9. Round | 17/04/2022 | CD Guabirá | - | Club Aurora | 3:2 | ||||
| 10. Round | 20/04/2022 | Club Aurora | - | Oriente Petrolero | 1:1 | ||||
| 11. Round | 24/04/2022 | Atlético Palmaflor | - | Club Aurora | 0:1 | ||||
| 13. Round | 08/05/2022 | Jorge Wilstermann | - | Club Aurora | 0:0 | ||||
| 15. Round | 15/05/2022 | Club Aurora | - | Nacional Potosí | 2:3 | ||||
| 16. Round | 21/05/2022 | The Strongest | - | Club Aurora | 1:0 |  |
Germany
USA