| 9. Round | 16/04/2022 | Santiago Wanderers | - | Puerto Montt | 2:0 | ||||
| 10. Round | 20/04/2022 | Deportes Melipilla | - | Santiago Wanderers | 2:0 | ||||
| 1. Round | 05/06/2022 | Santiago Wanderers | - | Deportes Iquique | 2:0 |  |
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| 11. Round | 09/06/2022 | Santiago Wanderers | - | Unión San Felipe | 0:1 | ||||
| 20. Round | 15/07/2022 | Santiago Morning | - | Santiago Wanderers | 1:2 |  |
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| 21. Round | 25/07/2022 | Santiago Wanderers | - | San Luis | 1:2 | |
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| 22. Round | 02/08/2022 | Rangers | - | Santiago Wanderers | 1:2 | ||||
| 23. Round | 07/08/2022 | Santiago Wanderers | - | Fernández Vial | 2:2 | ||||
| 24. Round | 12/08/2022 | CD Magallanes | - | Santiago Wanderers | 0:1 | ||||
| 19. Round | 16/08/2022 | Santiago Wanderers | - | Deportes Temuco | 3:0 | |
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| 27. Round | 06/09/2022 | Santiago Wanderers | - | Deportes Melipilla | 2:2 | ||||
| 28. Round | 10/09/2022 | Unión San Felipe | - | Santiago Wanderers | 2:3 | |
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| 30. Round | 03/10/2022 | Barnechea | - | Santiago Wanderers | 1:0 | ||||
| 31. Round | 09/10/2022 | Santiago Wanderers | - | Cobreloa | 2:2 | ||||
| 32. Round | 15/10/2022 | Universidad de Concepción | - | Santiago Wanderers | 1:1 |
Chile