10. Round | 20/11/2021 | Volos NFC | - | OFI Heraklion | 0:2 | ||||
12. Round | 04/12/2021 | OFI Heraklion | - | Olympiakos Piraeus | 1:3 | ||||
14. Round | 16/12/2021 | OFI Heraklion | - | Aris Saloniki | 1:1 | ||||
16. Round | 04/01/2022 | Asteras Tripolis | - | OFI Heraklion | 1:0 | ||||
19. Round | 22/01/2022 | OFI Heraklion | - | Panetolikos | 2:4 | ||||
23. Round | 13/02/2022 | OFI Heraklion | - | Volos NFC | 2:1 | ||||
22. Round | 16/02/2022 | Atromitos | - | OFI Heraklion | 2:2 | ||||
25. Round | 27/02/2022 | Olympiakos Piraeus | - | OFI Heraklion | 2:0 | ||||
26. Round | 06/03/2022 | OFI Heraklion | - | Apollon Smyrnis | 2:0 |