2. Round | 15/01/2022 | UANL Tigres [U20] | - | Puebla FC [U20] | 4:1 | ||||
3. Round | 21/01/2022 | Puebla FC [U20] | - | Club Tijuana [U20] | 0:2 | ||||
4. Round | 06/02/2022 | Gallos Blancos [U20] | - | Puebla FC [U20] | 0:2 | ||||
14. Round | 16/04/2022 | Club León [U20] | - | Puebla FC [U20] | 4:1 | ||||
15. Round | 19/04/2022 | CF Pachuca [U20] | - | Puebla FC [U20] | 2:2 | ||||
16. Round | 22/04/2022 | Puebla FC [U20] | - | Club Necaxa [U20] | 1:3 | ||||
17. Round | 29/04/2022 | Mazatlán FC [U20] | - | Puebla FC [U20] | 4:1 |