| 1. Round | 09/01/2016 | Club Tijuana | - | CF Pachuca | 1:1 | ||||
| 3. Round | 23/01/2016 | Club Tijuana | - | Santos Laguna | 1:3 | ||||
| 4. Round | 30/01/2016 | CD Veracruz | - | Club Tijuana | 2:2 | ||||
| 5. Round | 06/02/2016 | Club Tijuana | - | Cruz Azul | 1:1 |  |
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| 6. Round | 14/02/2016 | UANL Tigres | - | Club Tijuana | 1:2 | ||||
| 7. Round | 20/02/2016 | Club Tijuana | - | Monarcas Morelia | 1:1 | ||||
| 8. Round | 28/02/2016 | Deportivo Guadalajara | - | Club Tijuana | 1:1 | ||||
| 9. Round | 05/03/2016 | Club Tijuana | - | Club León | 0:0 | ||||
| 10. Round | 13/03/2016 | Chiapas FC | - | Club Tijuana | 1:2 | ||||
| 11. Round | 19/03/2016 | Club Tijuana | - | Deportivo Toluca | 0:0 | ||||
| 12. Round | 02/04/2016 | Club Tijuana | - | Gallos Blancos | 2:4 | ||||
| 13. Round | 09/04/2016 | CF América | - | Club Tijuana | 6:1 | ||||
| 14. Round | 16/04/2016 | Club Tijuana | - | CF Monterrey | 1:2 | ||||
| 15. Round | 23/04/2016 | Pumas UNAM | - | Club Tijuana | 3:1 | ||||
| 16. Round | 30/04/2016 | Club Tijuana | - | Puebla FC | 0:0 | ||||
| 17. Round | 08/05/2016 | Atlas Guadalajara | - | Club Tijuana | 0:0 |
USA
Mexico 