| 21. Round | 06/02/2021 | FC Emmen | - | AZ Alkmaar | 0:1 | ||||
| 22. Round | 12/02/2021 | RKC Waalwijk | - | FC Emmen | 1:0 | ||||
| 24. Round | 27/02/2021 | FC Utrecht | - | FC Emmen | 0:1 | ||||
| 25. Round | 05/03/2021 | FC Emmen | - | Sparta Rotterdam | 1:1 | ||||
| 26. Round | 13/03/2021 | FC Groningen | - | FC Emmen | 1:1 | ||||
| 27. Round | 20/03/2021 | Feyenoord | - | FC Emmen | 1:1 | ||||
| 28. Round | 04/04/2021 | FC Emmen | - | RKC Waalwijk | 3:1 | ||||
| 29. Round | 10/04/2021 | Fortuna Sittard | - | FC Emmen | 1:3 |  |
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| 30. Round | 25/04/2021 | FC Emmen | - | Heracles Almelo | 3:1 | ||||
| 31. Round | 02/05/2021 | AFC Ajax | - | FC Emmen | 4:0 | ||||
| 32. Round | 09/05/2021 | FC Emmen | - | FC Groningen | 0:4 | ||||
| 33. Round | 13/05/2021 | FC Emmen | - | sc Heerenveen | 3:1 | ||||
| 34. Round | 16/05/2021 | VVV-Venlo | - | FC Emmen | 0:4 | |
Netherlands