| 1. Round | 19/02/2022 | LDU Quito | - | Gualaceo SC | 1:0 | ||||
| 2. Round | 27/02/2022 | Gualaceo SC | - | Cumbayá | 0:1 | ||||
| 3. Round | 08/03/2022 | Deportivo Cuenca | - | Gualaceo SC | 2:1 | ||||
| 5. Round | 20/03/2022 | 9 de Octubre | - | Gualaceo SC | 1:1 | ||||
| 6. Round | 02/04/2022 | Gualaceo SC | - | Independiente del Valle | 1:3 | ||||
| 7. Round | 09/04/2022 | Técnico Universitario | - | Gualaceo SC | 1:1 | ||||
| 11. Round | 30/04/2022 | Gualaceo SC | - | Macará | 2:1 | ||||
| 12. Round | 08/05/2022 | Universidad Catolica | - | Gualaceo SC | 3:1 | ||||
| 13. Round | 17/05/2022 | Gualaceo SC | - | Guayaquil City | 2:1 | ||||
| 14. Round | 21/05/2022 | Delfín SC | - | Gualaceo SC | 1:0 |
Ecuador