| 6. Round | 15/09/2020 | Independiente Juniors | - | Gualaceo SC | 1:1 | ||||
| 7. Round | 17/09/2020 | Gualaceo SC | - | Manta | 0:1 | ||||
| 8. Round | 20/09/2020 | 9 de Octubre | - | Gualaceo SC | 2:1 | ||||
| 9. Round | 26/09/2020 | Gualaceo SC | - | América de Quito | 1:0 | ||||
| 10. Round | 03/10/2020 | Atlético Santo Domingo | - | Gualaceo SC | 0:1 | ||||
| 11. Round | 10/10/2020 | Gualaceo SC | - | Fuerza Amarilla | 1:1 |  |
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| 12. Round | 16/10/2020 | Gualaceo SC | - | Atlético Porteño | 1:1 | ||||
| 13. Round | 21/10/2020 | Santa Rita | - | Gualaceo SC | 3:1 | ||||
| 14. Round | 25/10/2020 | Gualaceo SC | - | Independiente Juniors | 1:0 | ||||
| 15. Round | 31/10/2020 | Manta | - | Gualaceo SC | 3:2 | |
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| 16. Round | 05/11/2020 | Gualaceo SC | - | 9 de Octubre | 3:2 | ||||
| 17. Round | 08/11/2020 | América de Quito | - | Gualaceo SC | 1:0 | ||||
| 18. Round | 14/11/2020 | Gualaceo SC | - | Chacaritas FC | 0:0 |
Ecuador