| 22. Round | 16/02/2008 | Rot Weiss Ahlen | - | Rot-Weiss Essen | 2:0 | ||||
| 23. Round | 23/02/2008 | Rot-Weiss Essen | - | Borussia Dortmund II | 0:0 |  |
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| 25. Round | 08/03/2008 | Rot-Weiss Essen | - | VfL Wolfsburg II | 3:0 | ||||
| 24. Round | 19/03/2008 | Kickers Emden | - | Rot-Weiss Essen | 0:0 | ||||
| 27. Round | 22/03/2008 | Rot-Weiss Essen | - | SV Babelsberg 03 | 1:2 | ||||
| 28. Round | 29/03/2008 | Rot-Weiß Erfurt | - | Rot-Weiss Essen | 4:0 | ||||
| 29. Round | 06/04/2008 | Rot-Weiss Essen | - | 1. FC Union Berlin | 0:3 | ||||
| 32. Round | 25/04/2008 | Rot-Weiss Essen | - | Werder Bremen II | 3:0 | ||||
| 35. Round | 11/05/2008 | Dynamo Dresden | - | Rot-Weiss Essen | 1:0 |
Netherlands