| Group C | 15/09/2021 | Sporting CP | - | AFC Ajax | 1:5 |  |
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| Group C | 28/09/2021 | Borussia Dortmund | - | Sporting CP | 1:0 | ||||
| Group C | 19/10/2021 | Beşiktaş | - | Sporting CP | 1:4 | |
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| Group C | 03/11/2021 | Sporting CP | - | Beşiktaş | 4:0 | |
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| Group C | 24/11/2021 | Sporting CP | - | Borussia Dortmund | 3:1 |  |
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| Group C | 07/12/2021 | AFC Ajax | - | Sporting CP | 4:2 | ||||
| Round of 16 | 15/02/2022 | Sporting CP | - | Manchester City | 0:5 | ||||
| Round of 16 | 09/03/2022 | Manchester City | - | Sporting CP | 0:0 | |
Portugal