| 7. Round | 27/02/2016 | Deportivo Capiatá | - | Club Nacional | 2:4 | ||||
| 8. Round | 02/03/2016 | Club Nacional | - | General Díaz | 1:3 | ||||
| 9. Round | 05/03/2016 | Cerro Porteño | - | Club Nacional | 1:2 | ||||
| 10. Round | 12/03/2016 | Club Nacional | - | Sportivo Luqueño | 1:1 | ||||
| 16. Round | 21/04/2016 | Libertad | - | Club Nacional | 4:3 | ||||
| 17. Round | 25/04/2016 | River Plate | - | Club Nacional | 1:3 |  |
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| 18. Round | 30/04/2016 | Club Nacional | - | Deportivo Capiatá | 0:1 | ||||
| 19. Round | 04/05/2016 | General Díaz | - | Club Nacional | 1:1 | ||||
| 20. Round | 09/05/2016 | Club Nacional | - | Cerro Porteño | 1:1 |
Paraguay