| 1. Round | 04/04/2021 | Deportes Temuco | - | San Luis | 2:2 | ||||
| 2. Round | 18/04/2021 | San Luis | - | Rangers | 0:1 | ||||
| 3. Round | 26/04/2021 | Puerto Montt | - | San Luis | 2:1 | ||||
| 4. Round | 03/05/2021 | San Luis | - | Unión San Felipe | 1:2 | ||||
| 5. Round | 09/05/2021 | Deportes Iquique | - | San Luis | 0:0 | ||||
| 7. Round | 25/05/2021 | San Luis | - | Deportes Copiapó | 1:2 |  |
Chile