| 3. Round | 29/01/2022 | Tecos Fútbol Club | - | Leones Negros II | 1:1 | ||||
| 4. Round | 05/02/2022 | Leones Negros II | - | Colima FC | 1:2 | ||||
| 5. Round | 12/02/2022 | Leones Negros II | - | Correcaminos UAT II | 0:1 | ||||
| 6. Round | 19/02/2022 | Coras de Nayarit | - | Leones Negros II | 3:0 |  |
|||
| 7. Round | 26/02/2022 | Leones Negros II | - | Mineros de Fresnillo FC | 0:0 | ||||
| 10. Round | 19/03/2022 | Cimarrones de Sonora II | - | Leones Negros II | 4:0 | ||||
| 11. Round | 26/03/2022 | Leones Negros II | - | Saltillo FC | 2:1 | ||||
| 8. Round | 29/03/2022 | Tuzos de la UAZ | - | Leones Negros II | 2:3 | ||||
| 12. Round | 02/04/2022 | Tritones Vallarta | - | Leones Negros II | 1:2 | |
|||
| 1. Round | 07/04/2022 | Gavilanes de Matamoros | - | Leones Negros II | 2:2 |  |
|||
| 13. Round | 10/04/2022 | Leones Negros II | - | Catedráticos Elite | 0:0 |
Mexico