| 1. Round | 08/01/2023 | CF Monterrey | - | Deportivo Guadalajara | 0:1 | ||||
| 2. Round | 14/01/2023 | Atlético San Luis | - | Deportivo Guadalajara | 0:0 | ||||
| 3. Round | 22/01/2023 | Deportivo Guadalajara | - | Deportivo Toluca | 1:2 | ||||
| 4. Round | 29/01/2023 | FC Juárez | - | Deportivo Guadalajara | 1:2 | ||||
| 5. Round | 05/02/2023 | Deportivo Guadalajara | - | Gallos Blancos | 1:1 | ||||
| 6. Round | 12/02/2023 | CF Pachuca | - | Deportivo Guadalajara | 1:1 | ||||
| 7. Round | 16/02/2023 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
| 9. Round | 26/02/2023 | UANL Tigres | - | Deportivo Guadalajara | 1:2 | ||||
| 10. Round | 05/03/2023 | Deportivo Guadalajara | - | Santos Laguna | 2:0 | ||||
| 11. Round | 11/03/2023 | Puebla FC | - | Deportivo Guadalajara | 1:0 | ||||
| 12. Round | 19/03/2023 | Deportivo Guadalajara | - | CF América | 2:4 | ||||
| 13. Round | 02/04/2023 | Atlas Guadalajara | - | Deportivo Guadalajara | 3:3 | ||||
| 14. Round | 09/04/2023 | Deportivo Guadalajara | - | Club Necaxa | 1:0 |  |
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| 15. Round | 16/04/2023 | Club León | - | Deportivo Guadalajara | 0:2 | |
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| 16. Round | 23/04/2023 | Deportivo Guadalajara | - | Cruz Azul | 2:1 |  |
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| 17. Round | 30/04/2023 | Deportivo Guadalajara | - | Mazatlán FC | 4:1 |
Mexico