| 1. Round | 09/07/2010 | Arsenal Kiev | - | Metalurg Zaporizhya | 1:0 |  |
|||
| 2. Round | 18/07/2010 | Metalurg Zaporizhya | - | Shakhtar Donetsk | 1:1 | ||||
| 3. Round | 25/07/2010 | Karpaty Lviv | - | Metalurg Zaporizhya | 1:0 | ||||
| 4. Round | 31/07/2010 | Metalurg Zaporizhya | - | Volyn Lutsk | 0:1 | |
|||
| 5. Round | 06/08/2010 | FK Illichivets | - | Metalurg Zaporizhya | 0:0 | ||||
| 7. Round | 22/08/2010 | Tavriya Simferopol (1958-2014) | - | Metalurg Zaporizhya | 2:0 | ||||
| 8. Round | 29/08/2010 | Metalurg Zaporizhya | - | Metalist Kharkiv | 0:2 | ||||
| 11. Round | 26/09/2010 | Vorskla Poltava | - | Metalurg Zaporizhya | 2:1 |  |
|||
| 14. Round | 23/10/2010 | PFK Sevastopol | - | Metalurg Zaporizhya | 1:0 | ||||
| 15. Round | 30/10/2010 | Metalurg Zaporizhya | - | Zorya Lugansk | 1:0 | ||||
| 16. Round | 06/11/2010 | Metalurg Zaporizhya | - | Arsenal Kiev | 2:1 | ||||
| 17. Round | 13/11/2010 | Shakhtar Donetsk | - | Metalurg Zaporizhya | 2:1 | ||||
| 18. Round | 21/11/2010 | Metalurg Zaporizhya | - | Karpaty Lviv | 0:0 | |
Poland