| 10. Round | 11/09/2022 | Santa Lucía | - | CSD Municipal | 1:0 | ||||
| 13. Round | 01/10/2022 | CSD Municipal | - | Achuapa | 1:1 | ||||
| 15. Round | 16/10/2022 | CSD Municipal | - | Antigua GFC | 0:1 |  |
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| 17. Round | 29/10/2022 | CSD Municipal | - | Comunicaciones | 2:3 | ||||
| 12. Round | 02/11/2022 | Cobán Imperial | - | CSD Municipal | 0:0 | |
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| 18. Round | 06/11/2022 | Deportivo Guastatoya | - | CSD Municipal | 1:3 |  |
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| 16. Round | 09/11/2022 | Deportivo Malacateco | - | CSD Municipal | 1:0 | ||||
| 19. Round | 12/11/2022 | CSD Municipal | - | Deportivo Mixco | 1:0 | ||||
| 21. Round | 23/11/2022 | CSD Municipal | - | Santa Lucía | 2:0 | ||||
| 22. Round | 27/11/2022 | Deportivo Xinabajul | - | CSD Municipal | 0:1 | |
Guatemala