| 1. Round | 20/07/2001 | Santos Laguna | - | Atlas Guadalajara | 3:1 | ||||
| 11. Round | 28/09/2001 | Santos Laguna | - | Deportivo Guadalajara | 0:1 | ||||
| 12. Round | 04/10/2001 | UAG Tecos | - | Santos Laguna | 1:2 | ||||
| 13. Round | 12/10/2001 | Puebla FC | - | Santos Laguna | 2:1 | ||||
| 15. Round | 26/10/2001 | Monarcas Morelia | - | Santos Laguna | 3:2 | ||||
| 16. Round | 02/11/2001 | Santos Laguna | - | CF América | 2:3 | ||||
| 17. Round | 09/11/2001 | CF Pachuca | - | Santos Laguna | 2:1 |  |
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| 18. Round | 16/11/2001 | Santos Laguna | - | UANL Tigres | 1:2 | ||||
| 19. Round | 23/11/2001 | Club Irapuato | - | Santos Laguna | 1:1 | |
Mexico