| 1. Round | 26/07/2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 1:1 |  |
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| 2. Round | 01/08/2021 | Santos Laguna [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 3. Round | 06/08/2021 | Club Necaxa [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 8. Round | 10/09/2021 | FC Juárez [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 12. Round | 03/10/2021 | Club Tijuana [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 14. Round | 19/10/2021 | Atlas Guadalajara [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 11. Round | 03/11/2021 | Cruz Azul [U20] | - | Club León [U20] | 2:0 | ||||
| 17. Round | 07/11/2021 | Pumas UNAM [U20] | - | Cruz Azul [U20] | 1:2 |
Mexico