1. Round | 12/09/2021 | Boston River | - | Montevideo Wanderers | 1:3 | ||||
2. Round | 17/09/2021 | Rentistas | - | Boston River | 1:2 | ||||
3. Round | 26/09/2021 | Boston River | - | Peñarol | 2:5 | ||||
4. Round | 03/10/2021 | Montevideo City Torque | - | Boston River | 4:3 | ||||
5. Round | 10/10/2021 | Boston River | - | Villa Española | 1:0 | ||||
12. Round | 14/11/2021 | Sud América | - | Boston River | 1:2 |