| 18. Round | 01/12/1990 | Lille OSC | - | SM Caen | 1:0 | ||||
| 19. Round | 08/12/1990 | AS Nancy Lorraine | - | Lille OSC | 1:1 |  |
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| 20. Round | 15/12/1990 | FC Nantes | - | Lille OSC | 0:0 | |
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| 21. Round | 22/12/1990 | Lille OSC | - | Girondins Bordeaux | 0:0 | ||||
| 22. Round | 12/01/1991 | Toulouse FC | - | Lille OSC | 2:2 | |
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| 23. Round | 19/01/1991 | Lille OSC | - | Olympique Marseille | 1:0 | ||||
| 25. Round | 02/02/1991 | Lille OSC | - | AS Monaco | 0:0 | ||||
| 26. Round | 09/02/1991 | AS Saint-Étienne | - | Lille OSC | 0:0 | ||||
| 28. Round | 23/02/1991 | Stade Brestois 29 | - | Lille OSC | 1:0 | ||||
| 27. Round | 26/02/1991 | Lille OSC | - | SC Toulon | 4:1 | ||||
| 29. Round | 01/03/1991 | Lille OSC | - | FC Sochaux | 0:1 | ||||
| 30. Round | 15/03/1991 | Stade Rennais | - | Lille OSC | 1:3 |  |
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| 31. Round | 22/03/1991 | Lille OSC | - | Paris Saint-Germain | 0:0 | ||||
| 33. Round | 11/04/1991 | Lille OSC | - | AJ Auxerre | 1:0 | ||||
| 34. Round | 19/04/1991 | OGC Nice | - | Lille OSC | 4:1 | |
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| 35. Round | 03/05/1991 | Lille OSC | - | Olympique Lyonnais | 1:1 | ||||
| 36. Round | 09/05/1991 | SM Caen | - | Lille OSC | 0:0 | ||||
| 37. Round | 16/05/1991 | Lille OSC | - | AS Nancy Lorraine | 0:2 | ||||
| 38. Round | 23/05/1991 | Lille OSC | - | FC Metz | 4:1 | |
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