1. Round | 18/04/2021 | Columbus Crew | - | Philadelphia Union | 0:0 | ||||
4. Round | 10/07/2021 | FC Cincinnati | - | Columbus Crew | 2:2 | ||||
4. Round | 18/07/2021 | Columbus Crew | - | New York City FC | 2:1 | ||||
4. Round | 22/07/2021 | Columbus Crew | - | Nashville SC | 0:0 | ||||
4. Round | 24/07/2021 | Atlanta United FC | - | Columbus Crew | 0:1 |