| 1. Round | 19/03/2022 | Pittsburgh Riverhounds | - | Hartford Athletic | 2:1 |  |
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| 2. Round | 10/04/2022 | Birmingham Legion | - | Hartford Athletic | 2:1 | ||||
| 2. Round | 17/04/2022 | Miami FC | - | Hartford Athletic | 2:0 |  |
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| 3. Round | 01/05/2022 | Indy Eleven | - | Hartford Athletic | 1:0 | ||||
| 3. Round | 29/05/2022 | Hartford Athletic | - | Phoenix Rising | 1:2 | |
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| 4. Round | 05/06/2022 | El Paso Locomotive | - | Hartford Athletic | 1:1 |  |
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| 4. Round | 12/06/2022 | San Diego Loyal | - | Hartford Athletic | 3:0 | ||||
| 4. Round | 16/06/2022 | Hartford Athletic | - | Memphis 901 | 1:1 | ||||
| 4. Round | 29/06/2022 | Hartford Athletic | - | Colorado Springs Switchbacks | 2:0 | ||||
| 5. Round | 07/07/2022 | Detroit City FC | - | Hartford Athletic | 1:1 | ||||
| 5. Round | 24/07/2022 | Hartford Athletic | - | Pittsburgh Riverhounds | 1:2 | ||||
| 5. Round | 28/07/2022 | Rio Grande Valley FC | - | Hartford Athletic | 0:0 | ||||
| 7. Round | 06/09/2022 | Los Angeles Galaxy II | - | Hartford Athletic | 1:3 | ||||
| 7. Round | 11/09/2022 | Hartford Athletic | - | FC Tulsa | 3:2 | ||||
| 7. Round | 18/09/2022 | Hartford Athletic | - | Las Vegas Lights FC | 3:0 | ||||
| 7. Round | 22/09/2022 | Loudoun United | - | Hartford Athletic | 3:0 |
Jamaica