| 1. Round | 07/08/2016 | Roda JC Kerkrade | - | Heracles Almelo | 1:1 | ||||
| 6. Round | 18/09/2016 | Heracles Almelo | - | AFC Ajax | 0:2 |  |
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| 7. Round | 24/09/2016 | FC Groningen | - | Heracles Almelo | 0:0 | ||||
| 8. Round | 02/10/2016 | Heracles Almelo | - | FC Twente | 1:1 | ||||
| 9. Round | 15/10/2016 | PSV Eindhoven | - | Heracles Almelo | 1:1 | ||||
| 10. Round | 23/10/2016 | sc Heerenveen | - | Heracles Almelo | 3:1 | ||||
| 13. Round | 19/11/2016 | Heracles Almelo | - | Go Ahead Eagles | 2:1 | ||||
| 14. Round | 27/11/2016 | AZ Alkmaar | - | Heracles Almelo | 5:1 | ||||
| 18. Round | 14/01/2017 | Heracles Almelo | - | FC Groningen | 1:4 | ||||
| 19. Round | 20/01/2017 | FC Twente | - | Heracles Almelo | 1:0 | ||||
| 20. Round | 28/01/2017 | Heracles Almelo | - | PSV Eindhoven | 1:2 | ||||
| 21. Round | 04/02/2017 | Willem II | - | Heracles Almelo | 1:3 |  |
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| 22. Round | 11/02/2017 | Heracles Almelo | - | Roda JC Kerkrade | 2:2 | ||||
| 23. Round | 18/02/2017 | Heracles Almelo | - | SBV Excelsior | 4:0 | ||||
| 34. Round | 14/05/2017 | Feyenoord | - | Heracles Almelo | 3:1 | |
Netherlands