| 1. Round | 31/07/2022 | Sigma Olomouc B | - | AC Sparta Praha B | 1:0 |  |
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| 2. Round | 07/08/2022 | AC Sparta Praha B | - | MFK Vyškov | 1:1 | ||||
| 3. Round | 13/08/2022 | Slavia Praha B | - | AC Sparta Praha B | 4:2 |  |
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| 4. Round | 21/08/2022 | AC Sparta Praha B | - | FC Sellier & Bellot Vlašim | 3:1 | ||||
| 5. Round | 27/08/2022 | MFK Chrudim | - | AC Sparta Praha B | 1:2 | |
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| 6. Round | 31/08/2022 | AC Sparta Praha B | - | Vysočina Jihlava | 1:3 | |
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| 7. Round | 04/09/2022 | FK MAS Táborsko | - | AC Sparta Praha B | 1:0 | ||||
| 8. Round | 09/09/2022 | MFK Karviná | - | AC Sparta Praha B | 2:0 | ||||
| 9. Round | 18/09/2022 | AC Sparta Praha B | - | SFC Opava | 1:0 | ||||
| 10. Round | 01/10/2022 | 1. SK Prostějov | - | AC Sparta Praha B | 0:2 | |
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| 11. Round | 09/10/2022 | AC Sparta Praha B | - | SK Líšeň | 0:0 | ||||
| 12. Round | 16/10/2022 | FK Varnsdorf | - | AC Sparta Praha B | 2:0 | ||||
| 13. Round | 23/10/2022 | AC Sparta Praha B | - | FK Třinec | 0:1 | |
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| 15. Round | 06/11/2022 | AC Sparta Praha B | - | FK Viagem Příbram | 0:3 | ||||
| 16. Round | 12/11/2022 | MFK Vyškov | - | AC Sparta Praha B | 3:1 |
Czech Republic