| 5. Round | 03/10/2010 | AO Kerkyra | - | Iraklis Saloniki | 0:0 | ||||
| 6. Round | 17/10/2010 | Iraklis Saloniki | - | Panserraikos | 1:1 | ||||
| 7. Round | 23/10/2010 | Asteras Tripolis | - | Iraklis Saloniki | 0:0 | ||||
| 8. Round | 31/10/2010 | Iraklis Saloniki | - | Olympiakos Volou | 0:0 | ||||
| 9. Round | 06/11/2010 | Skoda Xanthi | - | Iraklis Saloniki | 2:2 | ||||
| 10. Round | 15/11/2010 | Iraklis Saloniki | - | Aris Saloniki | 1:0 | ||||
| 11. Round | 20/11/2010 | Panathinaikos | - | Iraklis Saloniki | 4:2 | ||||
| 12. Round | 28/11/2010 | Panionios GSS | - | Iraklis Saloniki | 1:0 |  |
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| 16. Round | 05/01/2011 | Olympiakos Piraeus | - | Iraklis Saloniki | 2:0 | ||||
| 21. Round | 05/02/2011 | Panserraikos | - | Iraklis Saloniki | 1:2 | ||||
| 25. Round | 05/03/2011 | Aris Saloniki | - | Iraklis Saloniki | 0:1 | |
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| 26. Round | 12/03/2011 | Iraklis Saloniki | - | Panathinaikos | 1:3 | ||||
| 28. Round | 03/04/2011 | Ergotelis | - | Iraklis Saloniki | 1:0 | |
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| 30. Round | 17/04/2011 | AEK Athen | - | Iraklis Saloniki | 0:0 |
Greece