| 23. Round | 14/03/1981 | FC Utrecht | - | Go Ahead Eagles | 1:1 | ||||
| 24. Round | 28/03/1981 | Sparta Rotterdam | - | Go Ahead Eagles | 6:2 |  |
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| 25. Round | 03/04/1981 | Go Ahead Eagles | - | Roda JC Kerkrade | 5:1 | ||||
| 26. Round | 10/04/1981 | FC Wageningen | - | Go Ahead Eagles | 2:1 | ||||
| 27. Round | 17/04/1981 | Go Ahead Eagles | - | NAC Breda | 4:0 | ||||
| 28. Round | 24/04/1981 | PSV Eindhoven | - | Go Ahead Eagles | 1:1 | ||||
| 29. Round | 01/05/1981 | Go Ahead Eagles | - | SBV Excelsior | 4:2 | ||||
| 30. Round | 09/05/1981 | FC Groningen | - | Go Ahead Eagles | 3:1 | ||||
| 31. Round | 15/05/1981 | Go Ahead Eagles | - | FC Den Haag | 3:3 | ||||
| 32. Round | 22/05/1981 | AZ '67 Alkmaar | - | Go Ahead Eagles | 4:1 | ||||
| 33. Round | 29/05/1981 | Go Ahead Eagles | - | PEC Zwolle | 3:3 | ||||
| 34. Round | 05/06/1981 | SC NEC | - | Go Ahead Eagles | 2:3 |
Netherlands